About Parkinson’s Disease

About Parkinson’s Disease2018-02-02T04:07:39+00:00

Parkinson’s disease affects between 1 and 1.5 million Americans, with between 40,000 and 60,000 new cases diagnosed each year. The mean age of diagnosis is 62, although 5 to 10% of individuals with Parkinson’s disease have young-onset Parkinson’s, which manifests before the age of 45. Individuals may be diagnosed in the earlier or later stages of the disease, and symptoms may progress more rapidly in some people than others. However, there is a common pattern to the course of Parkinson’s disease, linked to the progressive loss of dopaminergic nerve cells in the brain and body.

Reduction of Levodopa Therapy for Dyskinesia

With ongoing Levodopa therapy for months or more commonly, a few years of treatment, two major types of motor complications tend to arise: motor fluctuations and dyskinesias. Motor fluctuations are variations in mobility associated with the effectiveness of levodopa when patients can tell when their medications kick in and wear off (the short duration response to levodopa). As the [...]

By |May 13th, 2022|Categories: Dyskinesia|0 Comments

Amantadine Products

Amantadine is also an older medication that was initially developed to help prevent influenza Type A. It was subsequently found to have a mild but definite effect on Parkinson’s without worsening typical symptoms. More recently, it has been found to be helpful in reducing levodopa-induced dyskinesias and now is predominantly used in advanced Parkinson’s disease for this purpose. Furthermore, [...]

By |May 13th, 2022|Categories: Dyskinesia|0 Comments

Invasive Therapies

Fortunately, there are more advanced options to consider if medical therapies do not seem to alleviate the symptoms of dyskinesia: Deep Brain Stimulation (DBS) Deep brain stimulation (DBS) should be considered for patients who have disabling motor fluctuations and dyskinesias despite optimal medication therapy or severe medication-refractory tremor.  Surgery should not be unnecessarily delayed when patients cannot practically be [...]

By |May 12th, 2022|Categories: Dyskinesia|0 Comments

Recognizing and Treating Dyskinesia

Although both dyskinesia and OFF episodes are common aspects of living with Parkinson's disease and become more prevalent later in the disease course. Levodopa-induced dyskinesia often involves involuntary muscle movements such as twitches, jerks, twisting and writhing. While "OFF" time occurs when Levodopa is wearing off and the patient has less control of their movements. These are referred [...]

By |April 5th, 2022|Categories: About Parkinson's Disease, De Novo|0 Comments

Inadequately Controlled Motor Fluctuations

Options Overview for Inadequately Controlled Motor Fluctuations As Parkinson’s disease progresses, the response to levodopa becomes more complex and medication beneficial effects begin to wear off between doses.   The variations in mobility such that patients can tell when their medications kick in and wear off are referred to as motor fluctuations.  Although motor fluctuations can be very frustrating and [...]

Go to Top