Research Catalyst

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So far Research Catalyst has created 17 blog entries.

Young Onset Parkinson’s Disease

2018-01-18T05:38:11+00:00By |Categories: Uncategorized|

Young Onset Parkinson’s Disease is defined by age of onset less than 40 years of age.  (Some authors use a looser definition of 50 years of age.)  Up to 10% of people with PD may be classified.  A higher percentage of young-onset patients have a genetic form of PD compared older or typical age of [...]

Newly Approved Medicines for Parkinson’s Disease

2018-03-11T04:46:30+00:00By |Categories: Established Treatments, New Treatments|

Nuplazid™ – The first and only FDA-approved therapy for hallucinations and delusions associated with psychosis in Parkinson’s Disease.  Nuplazid™ (also known by the generic name pimavanserin) works by blocking some of the effects of the neurotransmitter serotonin for which one of the specific receptors is expressed excessively especially in certain brain areas important in processing [...]

Medicines for Parkinson’s Disease

2018-03-21T18:40:16+00:00By |Categories: De Novo, Established Treatments|

The major classes of anti-Parkinson medication include carbidopa-levodopa (often referred to as Sinemet), catechol-o-methyltransferase inhibitors or COMT inhibitors, monoamine oxidase type B inhibitors, dopamine agonists, amantadine, and anticholinergics. Many of these medications are used in combinations although some of these may be used by themselves (in monotherapy) for treatment of symptoms of Parkinson’s disease. Levodopa [...]

Deep Brain Stimulation (DBS)

2018-03-21T19:14:54+00:00By |Categories: Established Treatments, Intermediate & Advanced PD|

Surgical treatment for Parkinson’s disease is indicated for patients who have disabling motor complications despite maximal drug therapy. This includes disabling levodopa-induced dyskinesias, medication-refractory disabling tremor or marked motor fluctuations in which there is variation in mobility from extremely immobile to good functioning. Surgical treatment is very helpful to treat motor complications, but with the [...]

Nutritional Supplements (not proven scientifically)

2018-03-11T04:44:58+00:00By |Categories: Established Treatments|

There are a wide variety of nutritional supplements which are marketed to patients with Parkinson’s disease (PD). Unfortunately, the production of nutritional supplements is not regulated by the FDA. Side effects may occur and drug interactions are not uncommon. Many supplements have been studied in a careful and scientific manner to determine if they are [...]

Exercise, Diet, and Therapy for Parkinson’s Disease

2018-03-21T19:15:31+00:00By |Categories: De Novo, Established Treatments, Intermediate & Advanced PD|

Exercise has shown to be helpful for maintenance of good health for normal individuals in the population. It has especially been demonstrated to improve a variety of different features of Parkinson’s disease including gait, strength, balance, and speed of movement. In the general population including patients with Parkinson’s disease, cardiovascular exercise improves cognitive function, mood, [...]

Non-Motor Symptoms of Parkinson’s Disease

2018-03-21T18:39:07+00:00By |Categories: About Parkinson's Disease, De Novo|

Often non-motor symptoms of Parkinson’s Disease can be overlooked and thought to be unassociated with PD, especially in the early stages of the disease. However, there are a variety of non-motor symptoms that can affect up to 50% of the PD population. Two of the major non-motor symptoms include cognitive changes and mood disorders. Cognitive [...]

Parkinson’s Disease Motor Symptoms

2018-01-18T05:23:25+00:00By |Categories: About Parkinson's Disease|

The most common motor symptoms of PD include tremor (occurring at rest), slowness of movements (bradykinesia), rigidity of movements in the limbs, trunk, and neck, and reduced balance. PD is a progressive neurological condition so symptoms, including motor symptoms, worsen over time. Tremor – Around 80% of PD patients have a tremor or will develop [...]

Causes of Parkinson’s Disease

2018-01-18T05:29:16+00:00By |Categories: About Parkinson's Disease|

The cause of Parkinson’s disease is unknown, however there are a number of genetic and environmental factors being studied as risk factors for the disease. Currently about 5- 10% of PD cases are thought to be monogenic and due to single mutations in genes known to be strongly causative for familial PD such as LRRK2, [...]

Atypical Parkinsonism & PSP

2018-01-18T05:47:24+00:00By |Categories: About Parkinson's Disease|

Atypical – Atypical Parkinsonism is a term used to cover a variety of neurodegenerative disorders in which parkinsonism occurs usually in conjunction with other signs not seen in PD.   About 15-20% of patients presenting with parkinsonism have a form of an atypical parkinsonism. The common causes of atypical parkinsonism include: Progressive Supranuclear Palsy (PSP) Multiple [...]